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Barbiturates must be administered in a lessened dosage and to the desired effect, and when injected intravenously really should be supplied slowly.The chemical composition of xylazine carefully resembles that of phenothiazines, tricyclic antidepressants, and clonidine. Xylazine is in the same drug class as clonidine, lofexidine, and dexmedetomidine